Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes.

ABSTRACT:

Introduction

Angiogenesis represents a potential therapeutic target in breast cancer. However, responses to targeted antiangiogenic therapies have been reported to vary among patients. This suggests that the tumor vasculature may be heterogeneous and that an appropriate choice of treatment would require an understanding of these differences.

Methods

To investigate whether and how the breast tumor vasculature varies between individuals, we isolated tumor-associated and matched normal vasculature from 17 breast carcinomas by laser-capture microdissection, and generated gene-expression profiles. Because microvessel density has previously been associated with disease course, tumors with low (n = 9) or high (n = 8) microvessel density were selected for analysis to maximize hetero

SUBMITTER: Pepin F 

PROVIDER: S-EPMC3680943 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature