Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk.

ABSTRACT:

Background

Results of studies of fluid consumption and its association with bladder cancer have been inconsistent. Few studies have considered modification effects from genetic variants that may interact with the type of consumed fluids. UDP-glucuronosyltransferases (UGTs), which are membrane-bound conjugating enzymes, catalyse the transformation of hydrophobic substrates to more water-soluble glucuronides to facilitate renal or biliary excretion. Whether genetic variants in UGTs could modulate the association between fluid intake and bladder cancer has not been studied.

Methods

We conducted a case-control study with 1007 patients with histopathologically confirmed bladder cancer and 1299 healthy matched controls. Fluid intake and epidemiologic data were collected via in-per

SUBMITTER: Wang J 

PROVIDER: S-EPMC3681021 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature