Genetic contribution and associated pathophysiology in end-stage renal disease.

ABSTRACT: End-stage renal disease (ESRD) or chronic kidney disease (CKD) is the terminal state of the kidney when its function has been permanently and irreversibly damaged. A wide variety of etiologies and pathological processes culminate in ESRD, and both environmental and genetic factors contribute to its development and progression. Various reports suggest that susceptibility to develop ESRD has a significant genetic component. These studies include familial aggregation studies, comparisons of incidence rates between different racial or ethnic populations, and segregation analysis. Genetic approaches have been used to identify genes that contribute to genetic susceptibility. Many studies have now been carried out assessing the contribution of specific "candidate genes", which correlate with diff

SUBMITTER: Agrawal S 

PROVIDER: S-EPMC3681165 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature