Allergic rhinitis and genetic components: focus on Toll-like receptors (TLRs) gene polymorphism.

ABSTRACT: Allergic rhinitis represents a global health issue affecting 10% to 25% of the population worldwide. Over the years, studies have found that allergic diseases, including allergic rhinitis, are associated with immunological responses to antigens driven by a Th2-mediated immune response. Because Toll-like receptors (TLRs) are involved in both innate and adaptive immune responses to a broad variety of antigens, the association between polymorphisms of TLRs and allergic diseases has been the focus in many animal and human studies. Although the etiology of allergic rhinitis is still unknown, extensive research over the years has confirmed that the underlying causes of allergic diseases are due to many genetic and environmental factors, along with the interactions among them, which include gene-

SUBMITTER: Gao Z 

PROVIDER: S-EPMC3681168 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature