External adjustment sensitivity analysis for unmeasured confounding: an application to coronary stent outcomes, Pennsylvania 2004-2008.

ABSTRACT:

Background

Assessing the real-world comparative effectiveness of common interventions is challenged by unmeasured confounding.

Objective

To determine whether the mortality benefit shown for drug-eluting stents (DES) over bare metal stents (BMS) in observational studies persists after controls for/tests for confounding.

Data sources/study setting

Retrospective observational study involving 38,019 patients, 65 years or older admitted for an index percutaneous coronary intervention receiving DES or BMS in Pennsylvania in 2004-2005 followed up for death through 3 years.

Study design

Analysis was at the patient level. Mortality was analyzed with Cox proportional hazards models allowing for stratification by disease severity or DES use propensity, accounting for clus

SUBMITTER: Huesch MD 

PROVIDER: S-EPMC3681250 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature