Glucocorticoid sensitivity in Behcet's disease.

ABSTRACT:

Objective

Glucocorticoid (GC) sensitivity is highly variable among individuals and has been associated with susceptibility to develop (auto-)inflammatory disorders. The purpose of the study was to assess GC sensitivity in Behçet's disease (BD) by studying the distribution of four GC receptor (GR) gene polymorphisms and by measuring in vitro cellular GC sensitivity.

Methods

Healthy controls and patients with BD in three independent cohorts were genotyped for four functional GR gene polymorphisms. To gain insight into functional differences in in vitro GC sensitivity, 19 patients with BD were studied using two bioassays and a whole-cell dexamethasone-binding assay. Finally, mRNA expression levels of GR splice variants (GR-α and GR-β) were measured.

Results

Healthy contr

SUBMITTER: Quax RA 

PROVIDER: S-EPMC3681319 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature