Association between inhaled nitric oxide treatment and long-term pulmonary function in survivors of acute respiratory distress syndrome.

ABSTRACT:

Introduction

Assessment of treatments for acute respiratory distress syndrome (ARDS) has focused on short-term outcomes (for example, mortality); little information exists regarding long-term effects of ARDS treatment. Survivors of ARDS episodes may have long-term obstructive/restrictive pulmonary abnormalities and pulmonary gas exchange impairment. A 2004 prospective randomized placebo-controlled trial assessed the efficacy and safety of inhaled nitric oxide (iNO) in patients with non-septic ARDS; the primary endpoint was days alive and off assisted breathing. This analysis examined potential effects of iNO or placebo on pulmonary function six months post-treatment in ARDS survivors from that original study.

Methods

ARDS survivors (N = 92) from a large-scale randomized, pla

SUBMITTER: Dellinger RP 

PROVIDER: S-EPMC3681348 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature