Enoxaparin sodium prevents intestinal microcirculatory dysfunction in endotoxemic rats.

ABSTRACT:

Introduction

During severe sepsis or septic shock, activation of the inflammatory and coagulatory systems can result in microcirculatory dysfunction as well as microvascular thrombosis, culminating in multiple organ dysfunction and death. Enoxaparin can inhibit factor Xa and attenuate endothelial damage. The primary purpose of this study was to investigate the effect of enoxaparin on intestinal microcirculation in endotoxemic rats.

Methods

Thirty male Wistar rats were divided into the following three groups: sham operated (OP); lipopolysaccharide (LPS); and LPS + Enoxaparin group. The rats received a midline laparotomy to exteriorize a segment of terminal ileum for microcirculation examination by full-field laser perfusion imager and sidestream dark field video microscope on

SUBMITTER: Yeh YC 

PROVIDER: S-EPMC3681388 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature