Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels.

ABSTRACT:

Background

Xenotropic Murine leukemia virus-Related Virus (XMRV) is a γ-retrovirus initially reported to be present within familial human prostate tumors and the blood of patients with chronic fatigue syndrome. Subsequent studies however were unable to replicate these findings, and there is now compelling evidence that the virus evolved through rare retroviral recombination events in human tumor cell lines established through murine xenograft experiments. There is also no direct evidence that XMRV infection has any functional effects that contribute to tumor pathogenesis.

Results

Herein we describe an additional xenotropic MLV, "B4rv", found in a cell line derived from xenograft experiments with the human prostate cancer LNCaP cell line. When injected subcutaneously in nude

SUBMITTER: Murgai M 

PROVIDER: S-EPMC3681559 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature