Transcriptional adaptation of pneumococci and human pharyngeal cells in the presence of a virus infection.

ABSTRACT:

Background

Viral upper respiratory tract infections are associated with increased colonization by Streptococcus pneumoniae but the mechanisms underlying this relationship are unclear. The objective of this study is to describe a comprehensive picture of the cellular interaction between the adhering bacteria and host cells in the presence or absence of a viral co-infection.

Results

Gene expression profiles of Detroit-562 pharyngeal cells, which were either mock-infected or infected with human respiratory syncytial virus (RSV) or human parainfluenza virus 3 (HPIV3), were analyzed using human microarrays. Transcription response of S. pneumoniae strain TIGR4 (serotype 4) in the presence of either mock- or viral-infected cells was analyzed by pneumococcal microarray. Significantl

SUBMITTER: Kimaro Mlacha SZ 

PROVIDER: S-EPMC3681581 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature