MEH Tyr113His polymorphism and the risk of ovarian cancer development.

ABSTRACT:

Background

The causes of ovarian cancer are complex and may be influenced by many factors, including polymorphism in the microsomal epoxide hydrolase (mEH) gene. Previous work suggests an association between the Tyr113His mEH polymorphism rs1051740 and susceptibility to ovarian cancer, but the results have been inconsistent.

Methods

PubMed, EMBASE, Google Scholar, and Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. A meta-analysis was performed to examine the association between Tyr113His mEH polymorphism and susceptibility to ovarian cancer. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results

Five studies involving 2,566 cases and 2,839 controls were included. Although the polymo

SUBMITTER: Zhong JH 

PROVIDER: S-EPMC3681615 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature