Dynamically regulated miRNA-mRNA networks revealed by exercise.

ABSTRACT:

Background

MiRNAs are essential mediators of many biological processes. The aim of this study was to investigate the dynamics of miRNA-mRNA regulatory networks during exercise and the subsequent recovery period.

Results

Here we monitored the transcriptome changes using microarray analysis of the whole blood of eight highly trained athletes before and after 30 min of moderate exercise followed by 30 min and 60 min of recovery period. We combined expression profiling and bioinformatics and analysed metabolic pathways enriched with differentially expressed mRNAs and mRNAs which are known to be validated targets of differentially expressed miRNAs. Finally we revealed four dynamically regulated networks comprising differentially expressed miRNAs and their known target mRNAs with

SUBMITTER: Tonevitsky AG 

PROVIDER: S-EPMC3681679 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature