Immune reconstitution after anti-thymocyte globulin-conditioned hematopoietic cell transplantation.

ABSTRACT:

Background aims

Anti-thymocyte globulin (ATG) is being used increasingly to prevent graft-versus-host disease (GvHD); however, its impact on immune reconstitution is relatively unknown. We (i) studied immune reconstitution after ATG-conditioned hematopoietic cell transplantation (HCT), (ii) determined the factors influencing the reconstitution, and (iii) compared it with non-ATG-conditioned HCT.

Methods

Immune cell subset counts were determined at 1-24 months post-transplant in 125 HCT recipients who received ATG during conditioning. Subset counts were also determined in 46 non-ATG-conditioned patients (similarly treated).

Results

(i) Reconstitution after ATG-conditioned HCT was fast for innate immune cells, intermediate for B cells and CD8 T cells, and very slow for

SUBMITTER: Bosch M 

PROVIDER: S-EPMC3681879 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature