Phenotypic identification and classification of functional defecatory disorders using high-resolution anorectal manometry.

ABSTRACT:

Background & aims

Disordered defecation is attributed to pelvic floor dyssynergia. However, clinical observations indicate a spectrum of anorectal dysfunctions. The extent to which these disorders are distinct or overlap is unclear; anorectal manometry might be used in diagnosis, but healthy persons also can have abnormal rectoanal pressure gradients during simulated evacuation. We aimed to characterize phenotypic variation in constipated patients through high-resolution anorectal manometry.

Methods

We evaluated anorectal pressures, measured with high-resolution anorectal manometry, and rectal balloon expulsion time in 62 healthy women and 295 women with chronic constipation. Phenotypes were characterized by principal components analysis of high-resolution anorectal manometr

SUBMITTER: Ratuapli SK 

PROVIDER: S-EPMC3681888 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature