Drug-induced liver injury caused by intravenously administered medications: the Drug-induced Liver Injury Network experience.

ABSTRACT:

Background and aims

Idiosyncratic drug-induced liver injury (DILI) can be caused by intravenous (IV) medications, but the characteristics of DILI caused by these agents are not known. The aim of this study is to characterize the clinical features of subjects with suspected DILI associated with IV agents enrolled into the Drug Induced Liver Injury Network Prospective Study.

Methods

Subjects with suspected DILI due to IV medications with probable, highly likely, or definite casuality scores were eligible.

Results

Between 2004 and October 2010, 542 cases of DILI were adjudicated for causality, of which 32 were eligible for inclusion in this study. DILI was ascribed to a single IV agent in 27 subjects, and to multiple IV agents in 5 subjects. Antimicrobial agents (62%), a

SUBMITTER: Ghabril M 

PROVIDER: S-EPMC3681898 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature