Family-based study of AVPR1B association and interaction with stressful life events on depression and anxiety in suicide attempts.

ABSTRACT: The cortisol response to psychosocial stress may become dysregulated in stress-related disorders. It is potentiated by pituitary secretion of adrenocorticotropic hormone (ACTH), which is, in part, regulated by arginine vasopressin receptor-1B (AVPR1B). AVPR1B variants were previously reported to associate with mood and anxiety disorders. This study aims, for the first time, to investigate association of AVPR1B genetic variants with mood and anxiety outcomes in suicidal behavior.Using a family-based study design of 660 complete nuclear family trios with offspring who have made a suicide attempt (SA), we tested the direct association and linkage of AVPR1B single nucleotide polymorphisms (SNPs) with SA, as well as with depression and anxiety in SA. Main findings were the association and linka

SUBMITTER: Ben-Efraim YJ 

PROVIDER: S-EPMC3682145 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature