Toll-like receptors expression and interferon-γ production by NK cells in human sepsis.

ABSTRACT:

Introduction

During the course of infection, natural killer (NK) cells contribute to innate immunity by producing cytokines, particularly interferon-gamma (IFN-γ). In addition to their beneficial effects against infection, NK cells may play a detrimental role during systemic inflammation, causing lethality during sepsis. Little is known on the immune status of NK cells in patients with systemic inflammatory response syndrome (SIRS) or sepsis in terms of cell surface markers expression and IFN-γ production.

Methods

We investigated 27 sepsis patients and 11 patients with non-infectious SIRS. CD56bright and CD56dim NK cell subsets were identified by flow cytometry and Toll-like receptor (TLR)2, TLR4, TLR9, CX3CR1, CD16 and CD69 expression were analyzed, as well as ex vivo IFN-γ

SUBMITTER: Souza-Fonseca-Guimaraes F 

PROVIDER: S-EPMC3682310 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature