Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading.

ABSTRACT:

Introduction

Critically ill ICU patients commonly develop severe muscle wasting and impaired muscle function, leading to delayed recovery, with subsequent increased morbidity and financial costs, and decreased quality of life for survivors. Critical illness myopathy (CIM) is a frequently observed neuromuscular disorder in ICU patients. Sepsis, systemic corticosteroid hormone treatment and post-synaptic neuromuscular blockade have been forwarded as the dominating triggering factors. Recent experimental results from our group using a unique experimental rat ICU model show that the mechanical silencing associated with CIM is the primary triggering factor. This study aims to unravel the mechanisms underlying CIM, and to evaluate the effects of a specific intervention aiming at reducing

SUBMITTER: Llano-Diez M 

PROVIDER: S-EPMC3682313 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature