Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children.

ABSTRACT:

Introduction

Differentiating between sterile inflammation and bacterial infection in critically ill patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) remains a clinical challenge. The objective of our study was to mine an existing genome-wide expression database for the discovery of candidate diagnostic biomarkers to predict the presence of bacterial infection in critically ill children.

Methods

Genome-wide expression data were compared between patients with SIRS having negative bacterial cultures (n = 21) and patients with sepsis having positive bacterial cultures (n = 60). Differentially expressed genes were subjected to a leave-one-out cross-validation (LOOCV) procedure to predict SIRS or sepsis classes. Serum concentrations of inte

SUBMITTER: Wong HR 

PROVIDER: S-EPMC3682317 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature