A follow-up association study of two genetic variants for bone mineral density variation in Caucasians.

ABSTRACT:

Summary

We tested whether two genetic variants were associated with BMD at multiple clinically relevant skeletal sites in Caucasians. We found that variant rs7776725 is consistently associated with hip, spine, wrist and whole-body BMD, which highlights the potential importance of this variant or linked variants for osteoporosis.

Introduction

A recent genome-wide association study identified two single nucleotide polymorphisms (SNPs), rs7776725 and rs1721400, that were associated with bone mineral density (BMD) variation at the radius, tibia and calcaneus in a Korean population. In this study, we aimed to test whether the association of these two genetic variants can be replicated in Caucasians and whether their association with BMD can be extended to other clinically relevan

SUBMITTER: Zhang LS 

PROVIDER: S-EPMC3682467 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature