Structural diversity of eukaryotic membrane cytochrome p450s.

ABSTRACT: X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These structures provide a basis for understanding structure-function relations that underlie their distinct catalytic activities. Moreover, structural plasticity has been characterized for individual P450s that aids in understanding substrate binding in P450s that mediate drug clearance.

SUBMITTER: Johnson EF 

PROVIDER: S-EPMC3682514 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature