Genetic variants and the risk of gestational diabetes mellitus: a systematic review.

ABSTRACT:

Background

Several studies have examined associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, inferences from these studies were often hindered by limited statistical power and conflicting results. We aimed to systematically review and quantitatively summarize the association of commonly studied single nucleotide polymorphisms (SNPs) with GDM risk and to identify important gaps that remain for consideration in future studies.

Methods

Genetic association studies of GDM published through 1 October 2012 were searched using the HuGE Navigator and PubMed databases. A SNP was included if the SNP-GDM associations were assessed in three or more independent studies. Two reviewers independently evaluated the eligibility for inclusion and

SUBMITTER: Zhang C 

PROVIDER: S-EPMC3682671 | biostudies-literature | 2013 Jul-Aug

REPOSITORIES: biostudies-literature