Trace amine associated receptor 1 modulates behavioral effects of ethanol.

ABSTRACT:

Background

Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and reinforcement-related effects of ethanol and whether it could potentially serve as a therapeutic target.

Methods

Wild-type (WT) and TAAR1 knockout (KO) mice (75% C57J/BL6 and 25% 129S1/Sv background) were compared in tests of ethanol consumption (two-bottle choice [TBC]), motor impairment (loss of righting reflex, [LORR], locomotor activity) and ethanol clearance (blood ethanol level [BEL]).

Results

As compared with WT mice, KO mice displayed (1) significantly greater preference for and consumption of ethanol in a TBC paradig

SUBMITTER: Lynch LJ 

PROVIDER: S-EPMC3682756 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature