Ontology highlight
ABSTRACT:
SUBMITTER: Amano T
PROVIDER: S-EPMC3682791 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
The developmental potency of mouse embryonic stem (ES) cells, which is the ability to contribute to a whole embryo, is known to deteriorate during long-term cell culture. Previously, we have shown that ES cells oscillate between Zscan4(-) and Zscan4(+) states, and the transient activation of Zscan4 is required for the maintenance of telomeres and genome stability of ES cells. Here we show that increasing the frequency of Zscan4 activation in mouse ES cells restores and maintains their developmen ...[more]