CWords - systematic microRNA regulatory motif discovery from mRNA expression data.

ABSTRACT:

Background

Post-transcriptional regulation of gene expression by small RNAs and RNA binding proteins is of fundamental importance in development of complex organisms, and dysregulation of regulatory RNAs can influence onset, progression and potentially be target for treatment of many diseases. Post-transcriptional regulation by small RNAs is mediated through partial complementary binding to messenger RNAs leaving nucleotide signatures or motifs throughout the entire transcriptome. Computational methods for discovery and analysis of sequence motifs in high-throughput mRNA expression profiling experiments are becoming increasingly important tools for the identification of post-transcriptional regulatory motifs and the inference of the regulators and their targets.

Results

cWor

SUBMITTER: Rasmussen SH 

PROVIDER: S-EPMC3682869 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature