Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors.

ABSTRACT:

Background

The widespread protozoan parasite Toxoplasma gondii interferes with host cell functions by exporting the contents of a unique apical organelle, the rhoptry. Among the mix of secreted proteins are an expanded, lineage-specific family of protein kinases termed rhoptry kinases (ROPKs), several of which have been shown to be key virulence factors, including the pseudokinase ROP5. The extent and details of the diversification of this protein family are poorly understood.

Results

In this study, we comprehensively catalogued the ROPK family in the genomes of Toxoplasma gondii, Neospora caninum and Eimeria tenella, as well as portions of the unfinished genome of Sarcocystis neurona, and classified the identified genes into 42 distinct subfamilies. We systematically compar

SUBMITTER: Talevich E 

PROVIDER: S-EPMC3682881 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature