Controlling false discovery rates in factorial experiments with between-subjects and within-subjects tests.

ABSTRACT:

Background

The False Discovery Rate (FDR) controls the expected number of false positives among the positive test results. It is not straightforward how to conduct a FDR controlling procedure in experiments with a factorial structure, while at the same time there are between-subjects and within-subjects factors. This is because there are P-values for different tests in one and the same response along with P-values for the same test and different responses.

Findings

We propose a procedure resulting in a single P-value per response, calculated over the tests of all the factorial effects. FDR control can then be based on the set of single P-values.

Conclusions

The proposed procedure is very easy to apply and is recommended for all designs with factors applied at differen

SUBMITTER: Schoen ED 

PROVIDER: S-EPMC3682898 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature