Integrated analysis of cytochrome P450 gene superfamily in the red flour beetle, Tribolium castaneum.

ABSTRACT:

Background

The functional and evolutionary diversification of insect cytochrome P450s (CYPs) shaped the success of insects. CYPs constitute one of the largest and oldest gene superfamilies that are found in virtually all aerobic organisms. Because of the availability of whole genome sequence and well functioning RNA interference (RNAi), the red flour beetle, Tribolium castaneum serves as an ideal insect model for conducting functional genomics studies. Although several T. castaneum CYPs had been functionally investigated in our previous studies, the roles of the majority of CYPs remain largely unknown. Here, we comprehensively analyzed the phylogenetic relationship of all T. castaneum CYPs with genes in other insect species, investigated the CYP6BQ gene cluster organization, functi

SUBMITTER: Zhu F 

PROVIDER: S-EPMC3682917 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature