Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium.

ABSTRACT: The atria respond to various pathological stimuli including pressure and volume overload with remodeling and dilatation. Dilatation of the left atrium is associated with atrial fibrillation. The mechanisms involved in chamber-specific hypertrophy are largely unknown. Angiotensin II is hypothesized to take part in mediating this response. ATF3 is an immediate early gene found at the receiving end of multiple stress and growth stimuli. Here we characterize ATF3 as a direct target gene for angiotensin II. ATF3 expression is regulated by angiotensin receptor-mediated signaling in vivo and in vitro at the transcriptional level. ATF3 induction is mediated by cooperation between both the AT(1A) and AT₂ receptor subtypes. While AT₂R blocker (PD123319) efficiently blocks ATF3 induction in response

SUBMITTER: Hasin T 

PROVIDER: S-EPMC3682928 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature