Germline mutational analysis of the C19orf62 gene in African-American women with breast cancer.

ABSTRACT: The past two decades have seen steady progress in the field of breast cancer genetics as we continually increase our understanding of how tumorigenesis results from damaged DNA. While BRCA1 and BRCA2 have taken center stage as indicators for breast cancer risk, we continue to identify other susceptibility genes and genomic regions, ever increasing our comprehension of breast cancer etiology. Through genome-wide association studies (GWAS), the 19p13 locus was found to contribute to breast and ovarian cancer risk. This region harbors a gene called C19orf62 whose protein has been reported to be a pivotal component in DNA damage repair. In this study, complete sequencing was performed to screen for deleterious mutations in the C19orf62 gene. In our cohort of 110 familial and 144 nonfamilial Af

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC3683071 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature