The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2.

ABSTRACT: Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central to this event is increased gene transcription. Small Rho-GTPases not only control the actin cytoskeleton, but are also implicated in gene regulation. However, in inflammation, it is not clear how this is regulated. Here, we show that the guanine-nucleotide exchange factor Trio expression is increased upon inflammatory stimuli in endothelium. Additionally, increased Trio expression was found in the vessel wall of rheumatoid arthritis patients. Trio silencing impaired VCAM-1 expression. Finally, we excluded that Trio-controlled VCAM-1 expression used the classical NFκB or MAP-kinase pathways, but rather acts on the transcriptional level by increasing phos

SUBMITTER: Van Rijssel J 

PROVIDER: S-EPMC3683159 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature