Converging paths to progress for skull base chordoma: Review of current therapy and future molecular targets.

ABSTRACT:

Background

Chordomas of the skull base are rare locally aggressive neoplasms with a predilection for encapsulating critical neurovascular structures, bony destruction and irregular growth patterns, and from which patients succumb to recurrence and treatment failures.

Methods

A review of the medical literature is performed, using standard search engines and identifying articles related to skull base chordomas, surgery, radiation therapy, chemotherapy, molecular genetics, and prospective trials.

Results

A synthesis of the literature is presented, including sections on pathology, treatment, molecular genetics, challenges, and future directions.

Conclusion

Beyond an understanding of the current treatment paradigms for skull base chordomas, the reader gains insight

SUBMITTER: Di Maio S 

PROVIDER: S-EPMC3683175 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature