Modelling and visualizing fine-scale linkage disequilibrium structure.

ABSTRACT:

Background

Detailed study of genetic variation at the population level in humans and other species is now possible due to the availability of large sets of single nucleotide polymorphism data. Alleles at two or more loci are said to be in linkage disequilibrium (LD) when they are correlated or statistically dependent. Current efforts to understand the genetic basis of complex phenotypes are based on the existence of such associations, making study of the extent and distribution of linkage disequilibrium central to this endeavour. The objective of this paper is to develop methods to study fine-scale patterns of allelic association using probabilistic graphical models.

Results

An efficient, linear-time forward-backward algorithm is developed to estimate chromosome-wide LD mode

SUBMITTER: Edwards D 

PROVIDER: S-EPMC3683336 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature