Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory viruses.

ABSTRACT: Severe respiratory viral infections are associated with spread to the alveoli of the lungs. There are multiple murine models of severe respiratory viral infections that have been used to identify viral and host factors that contribute to disease severity. Primary cultures of murine alveolar epithelial cells provide a robust in vitro model to perform mechanistic studies that can be correlated with in vivo studies to identify cell type-specific factors that contribute to pathology within the alveoli of the lung during viral infection. In this study, we established an in vitro model to compare the responses of type I (ATI) and type II (ATII) alveolar epithelial cells to infection by respiratory viruses used in murine models: mouse-adapted severe acute respiratory syndrome-associated coronavir

SUBMITTER: Kebaabetswe LP 

PROVIDER: S-EPMC3683362 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature