Genetic association of physically unlinked islands of genomic divergence in incipient species of Anopheles gambiae.

ABSTRACT: Previous efforts to uncover the genetic underpinnings of ongoing ecological speciation of the M and S forms of the African malaria vector Anopheles gambiae revealed two centromere-proximal islands of genetic divergence on X and chromosome 2. Under the assumption of considerable ongoing gene flow between M and S, these persistently divergent genomic islands were widely considered to be 'speciation islands'. In the course of microarray-based divergence mapping, we discovered a third centromere-associated island of divergence on chromosome 3, which was validated by targeted re-sequencing. To test for genetic association between the divergence islands on all three chromosomes, SNP-based assays were applied in four natural populations of M and S spanning West, Central and East Africa. Genotypin

SUBMITTER: White BJ 

PROVIDER: S-EPMC3683534 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature