CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection.

ABSTRACT:

Background

Mycobacterium tuberculosis infection in humans results in either latent infection or active tuberculosis. We sought to determine whether a higher frequency of regulatory T (T(reg)) cells predispose an individual toward active disease or whether T(reg) cells develop in response to active disease.

Methods

In cynomolgus macaques infected with a low dose of M. tuberculosis, approximately 50% develop primary tuberculosis, and approximately 50% become latently infected. Forty-one animals were monitored for 6-8 months to assess the correlation of the frequency of Foxp3(+) cells in peripheral blood and airways with the outcome of infection.

Results

In all animals, the frequency of T(reg) cells (CD4(+)Foxp3(+)) in peripheral blood rapidly decreased and simultaneousl

SUBMITTER: Green AM 

PROVIDER: S-EPMC3683560 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature