IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study.

ABSTRACT: The protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. The purpose of this study is to compare IMP3 immunostaining in squamous cellular skin tumor and determine whether IMP3 can aid in the differential diagnosis of these lesions. To our knowledge, IMP3 expression has not been investigated in skin squamous cell proliferations thus far. Immunohistochemical staining for IMP3 was performed on slides organized by samples from 67 patients, 34 with keratoacanthoma and 33 with primary squamous cell carcinoma (16 invasive and 17 in si

SUBMITTER: Soddu S 

PROVIDER: S-EPMC3683613 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature