Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

Animal studies have shown that vitamin K treatment reduced vascular calcification, but human data are limited.

Objective

We determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis by using a case-cohort design.

Design

Serum phylloquinone (vitamin K1) was measured in 296 participants with extreme CAC progression and 561 randomly selected participants without extreme CAC progression; all subjects had baseline and follow-up CAC measures (mean follow-up: 2.5 y). A serum vitamin K1 concentration was considered low at <1.0 nmol/L (the distribution median). Outcomes were replicated by using post hoc per-protocol analyses of a vitamin K1 supplementation trial.

Results

The

SUBMITTER: Shea MK 

PROVIDER: S-EPMC3683819 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature