The effects of tibolone in older postmenopausal women.

ABSTRACT:

Background

Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain.

Methods

In this randomized study, we assigned 4538 women, who were between the ages of 60 and 85 years and had a bone mineral density T score of -2.5 or less at the hip or spine or a T score of -2.0 or less and radiologic evidence of a vertebral fracture, to receive once-daily tibolone (at a dose of 1.25 mg) or placebo. Annual spine radiographs were used to assess for vertebral fracture. Rates of cardiovascular events and breast cancer were adjudicated by expert panels.

Results

During a median of 34 months of treatment, the tibolone group, as compared with the placebo group,

SUBMITTER: Cummings SR 

PROVIDER: S-EPMC3684062 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature