Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage.

ABSTRACT:

Background and purpose

Previous studies suggest that genetic variation plays a substantial role in occurrence and evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because of lack of large pedigree-based studies. However, a novel analytic tool based on genome-wide data allows heritability estimation from unrelated subjects. We sought to apply this method to provide heritability estimates for ICH risk, severity, and outcome.

Methods

We analyzed genome-wide genotype data for 791 ICH cases and 876 controls, and determined heritability as the proportion of variation in phenotype attributable to captured genetic variants. Contribution to he

SUBMITTER: Devan WJ 

PROVIDER: S-EPMC3684199 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature