Analysis of the use of codon pairs in the HE gene of the ISA virus shows a correlation between bias in HPR codon-pair use and mortality rates caused by the virus.

ABSTRACT:

Background

Segment 6 of the ISA virus codes for hemoagglutinin-esterase (HE). This segment is highly variable, with more than 26 variants identified. The major variation is observed in what is called the high polymorphism region (HPR). The role of the different HPR zones in the viral cycle or evolution remains unknown. However viruses that present the HPR0 are avirulent, while viruses with important deletions in this region have been responsible for outbreaks with high mortality rates. In this work, using bioinformatic tools, we examined the influence of different HPRs on the adaptation of HE genes to the host translational machinery and the relationship to observed virulence.

Methods

Translational efficiency of HE genes and their HPR were estimated analyzing codon-pair bias

SUBMITTER: Tello M 

PROVIDER: S-EPMC3684539 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature