Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization.

ABSTRACT: hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

SUBMITTER: Mishra A 

PROVIDER: S-EPMC3684849 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature