Testing for associations between loci and environmental gradients using latent factor mixed models.

ABSTRACT: Adaptation to local environments often occurs through natural selection acting on a large number of loci, each having a weak phenotypic effect. One way to detect these loci is to identify genetic polymorphisms that exhibit high correlation with environmental variables used as proxies for ecological pressures. Here, we propose new algorithms based on population genetics, ecological modeling, and statistical learning techniques to screen genomes for signatures of local adaptation. Implemented in the computer program "latent factor mixed model" (LFMM), these algorithms employ an approach in which population structure is introduced using unobserved variables. These fast and computationally efficient algorithms detect correlations between environmental and genetic variation while simultaneously

SUBMITTER: Frichot E 

PROVIDER: S-EPMC3684853 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature