The relationship between infant lung function and the risk of wheeze in the preschool years.

ABSTRACT:

Rationale

There is evidence that perinatal lung development predicts childhood wheeze. However, very few studies have examined whether preschool wheeze is associated with lower premorbid lung function in early infancy, and as yet there is no information relating atopic and non-atopic preschool wheeze to early lung development.

Objective

To examine the association between premorbid infant lung function and preschool wheeze, and to explore associations with atopic and non-atopic wheeze phenotypes.

Methods

Infant lung function was measured in 147 healthy term infants aged 5-14 weeks. Rapid thoracoabdominal compression was performed during tidal breathing and at raised volume to measure maximal expiratory flow at functional residual capacity (V' max FRC) and forced expira

SUBMITTER: Pike KC 

PROVIDER: S-EPMC3685268 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature