Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans.

ABSTRACT:

Background

Beta-trace protein (BTP), measured in serum or plasma, has potential as a novel biomarker for kidney function. Little is known about the genes influencing BTP levels.

Methods

We conducted a genome-wide association study of log-transformed plasma BTP levels in 6720 European Americans (EAs) and replicated the significant associations in 1734 African Americans (AAs) from the Atherosclerosis Risk in Communities (ARIC) study.

Results

We identified a genome-wide significant locus in EA upstream of Prostaglandin D2 synthase (PTGDS), the gene encoding BTP. Each copy of the A allele at rs57024841 was associated with 5% higher BTP levels (P = 1.2 × 10(-23)). The association at PTGDS was confirmed in AAs (6% higher BTP for each A allele at rs57024841, P = 1.9 × 10(-7)

SUBMITTER: Tin A 

PROVIDER: S-EPMC3685304 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature