Quantitative analysis of FJ 194940.1 gene expression in colon cancer and its association with clinicopathological parameters.

ABSTRACT:

Aim of the study

The FJ 194940.1 gene is located on chromosome 1 and consists of 6 exons and 5 introns. The gene undergoes alternative splicing and its isoforms appear during cancer development. Evidence suggests that expression of FJ 194940.1 splice variants relate to colorectal cancer progression. This paper discusses the quantitative analysis of the exon V expression level of FJ 194940.1 in colon cancer. The aim of the study is to carry out quantitative analysis by real-time PCR in a series of 102 colon cancer samples that had previously shown presence of exon V expression. To compare the exon V expression level with certain histological parameters and clinical staging of the neoplasm in order to assess its potential role as a prognostic factor in colon cancer.

Material and m

SUBMITTER: Bartczak-Tomczyk M 

PROVIDER: S-EPMC3685339 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature