Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia.

ABSTRACT: Subcortical dopamine system dysregulation has been suggested to underlie the positive symptoms of schizophrenia. Recent preclinical investigations and human imaging studies have proposed that the augmented dopamine system function observed in schizophrenia patients may be secondary to aberrant hippocampal activity. Thus, we posit that the hippocampus represents a novel therapeutic target for the treatment of schizophrenia. Here we provide evidence of the effectiveness of a unique approach aimed at decreasing hippocampal function in a rodent model of schizophrenia. Specifically, in a rodent model of schizophrenia, we demonstrate that ventral hippocampal (vHipp) deep brain stimulation (DBS) can normalize aberrant dopamine neuron activity and behaviours associated with positive symptoms. In a

SUBMITTER: Perez SM 

PROVIDER: S-EPMC3685478 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature