Within-host and between-host evolutionary rates across the HIV-1 genome.

ABSTRACT:

Background

HIV evolves rapidly at the epidemiological level but also at the within-host level. The virus' within-host evolutionary rates have been argued to be much higher than its between-host evolutionary rates. However, this conclusion relies on analyses of a short portion of the virus envelope gene. Here, we study in detail these evolutionary rates across the HIV genome.

Results

We build phylogenies using a relaxed molecular clock assumption to estimate evolutionary rates in different regions of the HIV genome. We find that these rates vary strongly across the genome, with higher rates in the envelope gene (env). Within-host evolutionary rates are consistently higher than between-host rates throughout the HIV genome. This difference is significantly more pronounced in en

SUBMITTER: Alizon S 

PROVIDER: S-EPMC3685529 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature