MRI and cerebrospinal fluid biomarkers for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: a diagnostic accuracy study.

ABSTRACT:

Objectives

To assess the incremental value of MRI and cerebrospinal fluid (CSF) analysis after a short memory test for predicting progression to Alzheimer's disease from a pragmatic clinical perspective.

Design

Diagnostic accuracy study in a multicentre prospective cohort study.

Setting

Alzheimer Disease Neuroimaging Initiative participants with complete data on neuropsychological assessment, MRI of the brain and CSF analysis.

Participants

Patients with mild cognitive impairment (MCI; n=181) were included. Mean follow-up was 38.9 months (range 5.5-75.9).

Main outcome measures

Diagnostic accuracy of individual instruments and incremental value of entorhinal cortex volume on MRI and p-τ/Aβ ration in CSF after administration of Rey's Auditory Verbal Learnin

SUBMITTER: Richard E 

PROVIDER: S-EPMC3686215 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature