An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease.

ABSTRACT:

Background

Graves' disease is a female preponderant autoimmune illness and the contribution of the X chromosome to its risk has long been appreciated. However, no X-linked susceptibility loci have been indentified from recent genome-wide association studies (GWAS).

Methods

We re-examined the X chromosome data from our recent GWAS for Graves' disease by including males that were previously excluded from the X chromosome analyses. The data were analysed using logistic regression analysis including sex as a covariate, and an additive method assuming X chromosome inactivation, implemented in snpMatrix.

Results

A cluster of single nucleotide polymorphism (SNPs) at Xq21.1 was found showing association with genome-wide significance, among which rs3827440 was a non-synonymous

SUBMITTER: Chu X 

PROVIDER: S-EPMC3686253 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature